Massively parallel oligonucleotide and peptide synthesis on a microchip based on the µParaflo® microfluidics technology
Our scientists and engineers have developed platform technologies that encompass a new class of microfluidic µParaflo® reaction devices, an advanced digital light synthesizer apparatus, and picoliter scale biochemical processes. The functionalized µParaflo® chips are particularly suited for applications where small sample consumption, contamination-free, and performance-reproducibility are primary concerns. This technology enables the massively parallel synthesis of high quality DNA and RNA oligonucleotides as well as peptides and peptidomimetics in picoliter-scale reaction chambers.
The only platform providing microarrays of oligonucleotide, peptide, and their analog sequences by in situ synthesis using conventional chemistry and a comprehensive list of off-the-shelf synthetic building blocks.
High Density – On Chip Parallel Synthesis
Customizable – DNA, RNA, Peptides, and Analogs
Versatile – Uses Conventional Chemistry
Clear Advantages :
The synthesis method is suitable for different classes of molecules, such as oligonucleotides, peptides, or their analogs.
The synthesis can be performed in a regular research laboratory.
The synthesis efficiency can be optimized to be comparable with conventional synthesis.
It offers flexibility in the sequences to be synthesized – editing the changes in sequence text files to create different chips easily.
The overall consumption of chemicals (in synthesis) and samples (in assays) is significantly reduced to the level of sub-nanoliter to picoliter per assay.
The microfluidic reaction chambers are particularly suited for parallel biochemical reactions.
The liquid delivery to the microchip is simple (parallel flow through the inlet and outlet holes), can be automated, and there is little chance of ambient contamination.
The spot density of the chip can be ten-fold higher than that of spotted chip.
