This LinkAGE webinar looks at how whole genome sequencing can be utilised to more effectively target chemotherapies to specific tumours, as well as when clinicians can use genomic data as a guide for when not to use chemotherapies. It was presented by consultant paediatric oncologist Dr Sam Behjati. We have provided timestamps, video chapters and transcriptions (coming soon) to help you find what you need. The webinar and Q&A was broadcast live on 11 May 2023.

By the end of this LinkAGE webinar you will have:

- reflected on what WGS is and the technology underlying it;
- explored how WGS helps us to treat patients and target therapy; and
- evaluated the benefits of the NHS programme.

What is the LinkAGE expert webinar series?
The Genomics Education Programme's LinkAGE (Linking Academia and Genomics Education) series will aim to provide expert seminars on exciting ‘bench-to-bedside’ projects that are likely to impact on clinical practice in the not-too-distant future.

Who is the LinkAGE expert webinar series aimed at?
This webinar series is aimed at researchers, clinicians and other healthcare professionals who already have a strong understanding of fundamental genomics concepts. If you are just starting your learning journey, or need a quick refresher, we encourage you to visit our website: www.genomicseducation.hee.nhs.uk

Meet the speaker
Dr Behjati is an academic paediatric oncologist who combines clinical work with research on childhood cancer. His group, based at the Wellcome Sanger Institute, uses quantitative genomic data to reveal the origins of childhood cancer. Originally from Germany, he read medicine at Oxford University before pursuing by academic clinical training in London and Cambridge.

TIMESTAMPS
00:00 Introductions and talk overview
01:56 What is cancer, to our genome?
07:20 How does a childhood cancer genome differ from that of an adult?
12:43 WGS, paediatric oncology and equitable access
16:22 Patient and parents' perspective and NHS service implications
20:11 100,000 genomes project and paediatric genomes
27:22 Case study 1: Treatment of a 10 year old with Wilms tumour-like genomic changes in RCC
31:09 Case study 2: 16 month old's tumour treatment decided after WGS
36:00 The 'live programme' at Cambridge
39:02 Case study 3: Baby with unknown mass achieves diagnosis
41:14 Conclusions on WGS in paediatric oncology
42:30 Wrap up and Q&A

Footnote
The Genomics Education Programme is developing a substantial education programme to inform healthcare professionals about the impact of genomics on clinical practice. This video is the one of the many educational resources from the programme.

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