Chris Simms and Mike Florio discuss the recent struggles and injury problems the San Francisco 49ers have faced, which then could possibly lead to a Buffalo Bills victory on Sunday night. #NBCSports #ChrisSimmsUnbuttoned #NFL
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'Chris Simms Unbuttoned' features in-depth Xs and Os NFL analysis; one-on-one interviews with players, coaches, executives, and draft prospects; game recaps and previews; gambling segments; extensive player analysis leading into the NFL draft; and much more.

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NFL Week 13 preview: San Francisco 49ers vs. Buffalo Bills | Chris Simms Unbuttoned | NFL on NBC
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