Charles Brenner is a leading Global expert in the biology, chemistry and Medicine of NAD the central Catalyst of metabolism he currently works at City of Hope in Los Angeles as professor and chair of the Department of diabetes and cancer metabolism.
I'm intrigued by Charles' recent rebuttal to David Sinclair's thesis regarding longevity. "Surtuins are not conserved longevity genes" published in the Journal of Life metabolism in October 2022.
In this episode Charles and I discuss this paper and his view on the science of longevity. We will expand on this while also discussing various other topics related to NAD, use cases for NR, metabolism and where influencers go wrong in the nutrition space.
If you have any additional questions you would like answered in the future, let me know in the comments.
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Chapters:
00:00:00 - The Role of NAD in Metabolism and Living Things
00:11:18 - NAD and the De Novo Pathway
00:21:50 - The Composition of NAD and NR
00:33:07 - The Innate Immune Response and NAD Churning
00:44:08 - The Longevity of Naked Mole Rats and Humans
00:55:27 - The Myth of Sirtuin Genes and Longevity
01:06:26 - Reproducibility Issues and False Claims
01:17:32 - Targeting the Aging System
01:27:44 - The Uselessness of Age Tests
01:38:26 - Q&A on Twitter
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Connect with Dr Charles Brenner:
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- Website: [ Ссылка ]
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Connect with Dr Charles Brenner:
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- Website: [ Ссылка ]
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